Evaluation of Curative Effect and Safety ofβ1 Receptor Blockers in Patients with Diagnosis of the Chronic Obstructive Pulmonary Disease with ;Coronary Heart Disease
Abstract：Objective:To observe the curative effect and safety ofβ1 receptor blockers in patients with chronic obstructive pulmonary disease(COPD) and coronary heart disease(CHD).Method:Eighty-eight patients with the diagnosis of COPD and CHD were selected for this study,who were used to be hospitalized in our department from March 2011 to February 2015,all of them were randomly divided into control group and treatment group.The control group was prescribed the routine therapy,the treatment group were given conventional therapy plus metoprolol sustained-release tablets.The pulmonary function,B type natriuretic peptide(BNP),acute physiology and chronic health status score (APACHEⅡ) were observed of the two groups before and after treatment.Result:After treatment, the two groups of patients with lung function,BNP and APACHEⅡscores were significantly improved than before treatment(P<0.05).After 1 month of treatment, the changes of pulmonary function in the treatment group compared with the control group,the difference was not statistically significant(P>0.05),BNP and APACHEⅡscores improved significantly compared with the control group,the difference was statistically significant(P<0.05).Pearson correlation analysis showed that the use ofβ1 receptor blockers and APACHE score,BNP levels and adverse events were negatively correlated.Conclusion:β1 receptor blockers in COPD with CHE are safely and effectively capable to improve cardiac function and do not affect lung function.
Keywords：Chronic obstructive pulmonary diseaseIschemic heart diseaseBeta receptor blocker
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 6-8 )