Determination and Clinical Significance of Serum IL-18,IL-6 and NO of Retreatment TB Patients

LI Ling; ZHENG Ding-rong

doi:10.14033/j.cnki.cfmr.2016.21.003

Abstract：Objective:To discuss the change of serum interleukin-18(IL-18),interleukin-6(IL-6) and nitric oxide(NO) expression levels in retreatment TB patients and its significance.Method:120 cases of retreatment TB patients in Bao’an District Central Hospital of Shenzhen City from January 2012 to December 2014 were selected as the observation group.28 cases with 2 types or less than 2 types of drug resistance were as the low resistance group,45 cases with 3 or 4 types of drug resistance were as the moderate resistance group,47 cases with more than 4 types of drug resistant were as the high resistant group.After treatment,66 cases who were cured were as the treated group,54 cases who were not cured were as the untreated group.Simultaneously 60 cases of normal healthy people were selected as the control group.They were respectively fasted venous blood.The serum NO,IL-18,IL-6 levels of different groups were analyzed and compared.Result:Before treatment,the serum levels of IL-18,IL-6 and NO were significantly higher than those of the control group,the differences were statistically significant(P<0.05).The serum levels of IL-18,IL-6 and NO from high to low were the high resistance group>the moderate resistance group>the low resistance group,the differences were statistically significant(P<0.05).After treatment,the serum levels of IL-18,IL-6 and NO of the two groups were lower than before,the serum levels of IL-18,IL-6 and NO of the treated group were lower than those of the untreated group,the differences were statistically significant(P<0.05).There were no statistically significant differences in the serum levels of IL-18,IL-6 and NO between the treated group and the control group(P>0.05).Conclusion:IL-18,IL-6 and NO are important regulators of immune cytokines of TB infection.Serum levels of IL-18,IL-6 and NO are in direct proportion to multidrug resistant species,their serum levels can be the key indicators monitoring the disease activity and outcome of retreatment TB patients and they can predict the effectiveness of treatment program of retreatment tuberculosis.