Reports of Allergic Reactions of Doxycycline Hydrochloride in the Treatment of Brucellosis Investigation

doi:10.14033/j.cnki.cfmr.2016.19.034

Abstract：Objective:To discuss the curative effect and incidence of allergic reactions of Doxycycline Hydrochloride in the treatment of patients infected with brucella bacillus disease(brucella).Method:1168 cases of brucella infection from January 2014 to July 2015 were selected as the research objects and retrospective analyzed,the patient’s curative effect and adverse reactions were observed after treating with Doxycycline Hydrochloride.Result:Since 2014,a total of 20 cases of Doxycycline Hydrochloride allergy were reported in the city of Luoyang,the average incidence was 1.71%,which included 6 cases in 2014,the incidence was 0.91%,and 14 cases in 2015,the incidence was 2.81%,the difference was statistic significant(P<0.05);The incidence has statistically difference among different ages,patients under 30 years old were the most(P<0.05).The signs and symptoms of allergic reactions were given priority to rashes and pruritus all over the body.Conclusion:The allergic reactions of Doxycycline Hydrochloride are diversification in the treatment of brucella infection,the experiences should summarized to prevent and control the new disease burden caused by the allergic reaction of Doxycycline Hydrochloride treatment.It is suggested periodical inspections on blood routine examination and liver function in the early,middle and late treatment period when taking Doxycycline Hydrochloride for the treatment of brucella,and receive treatment processing in time if finding unusual.