The Clinicopathologic Analysis of Yolk Sac Tumor in 32 Cases

LI Feng; CHEN Xiao-yan

doi:10.14033/j.cnki.cfmr.2016.17.025

Abstract：Objective:To improve the cognition about the yolk sac tumor(YST) by exploring the clinicopathological characteristics,immunohistochemical characteristics,diagnosis and differential diagnosis of YST.Method:Thirty-two cases of YST were selected and the clinicopathological characteristics and immunohistochemical staining were retrospective analyzed,and the relevant literature were reviewed and compared.Result:Among the 32 cases with YST,19 cases in males,13 cases in female,the average years old was 12.6 ranging from 7 months to 50 years old.As to the occurrence site,17 cases were found in testis,10 cases were found in ovary and 5 cases were found in extragonadal sites.The microscopical result showed characteristic Schiller-Duval bodies,loose reticular structure and hyaline droplets in the tumor tissue.The immunohistochemistry showed Glypican-3,CK and SALL4 were expressed in all of cases,while CD30,hCG,CD117,EMA,CD15,CK7,ER and PR were not expressed in all of the cases.The expression of AFP with different levels were found in 28 cases.Vimentin were expressed in 20 cases.The spotty expression of PLAP was showed in 5 cases.The spotty expression of OCT4 was showed in only 2 cases.The proliferative index of Ki-67 was more than 50%.Conclusion:YST is a rare germ cell tumor,which is easy to be misdiagnosed when appeared in extragonadal sites. The correct diagnosis of YST is mainly depended on histopathology and immunohistochemical staining.