The Application of Surgical and Nonsurgical Methods in Treatment of Multiple Intracranial High-grade Gliomas

LIU Sheng-yuan

doi:10.14033/j.cnki.cfmr.2016.16.005

Abstract：Objective:To study the effect of the application of surgical and nonsurgical in treatment of multiple intracranial high-grade gliomas. Method:The clinical data of 52 patients with multiple intracranial high-grade gliomas hospitalized in our hospital neurosurgery from January 2009 to January 2013 were retrospective analyzed,according to the different therapies,they were divided into group A(the surgery group,37 cases) and group B(the non-surgery group,15 cases).The surgery condition,survival time and the incidence of early complications between the two groups were compared.Result:The pathological and radiographic data between the two groups showed no significant difference(P>0.05).After hospital discharge,patients were followed up for a period of 1 to 24 months,all patients relapsed and dead without any loss of cases.The survival time in group A was significantly longer than that in group B,the difference was statistically significant(P<0.05).Patients in group A occurred 3 cases of severe cerebral edema,2 cases of intracranial infection,2 cases of limb movement disorder occurs, 2 cases of mental disorders.Group B patients’ biopsy showed no postoperative complications.The early complications occurred in group A was 24.3%(9/37), significantly higher than that in group B,the difference was statistically significant(P<0.05).Conclusion:Surgical resection of multiple intracranial high-grade gliomas can significantly prolong the survival of patients, which should be application in clinic,while some elder patients with poor physical fitness may not tolerate the surgery,who should be carefully on the choice.