The Effects of Pretreatment with Atorvastatin on Coronary Artery Spasm
Abstract：Objective:To explore the effect of pretreatment with atorvastatin on Pituitrin(Pit)-induced coronary artery spasm of rats.Method:Forty male SD rats were randomly divided into four groups.Every group had 10 rats.The control group was non-drug intervention.The Atorvastatin group was given orally Atorvastatin[5 mg/(kg·d)] by gastric gavage for 15 days.The Nifedipine group was given orally Nifedipine[5 mg/(kg·d)] by gastric gavage for 15 days.The combined group was given orally Atorvastatin[5 mg/(kg·d)] and Nifedipine[5 mg/(kg·d)] by gastric gavage for 15 days.After 15 days continuous administration to all the groups of rats,we created the coronary artery spasm by injecting Pit into caudal vein of rats.To monitor the Ⅱ Load Electrocardiogram and record the Cardiographs of all the groups at the time of pre-injection(0 s),post-injection(30 s,l,3,5,7 min) of the Pit.Compared the change range of the J point,the arrhythmogenesis rate and heart rate at all of the timing points.Result:After injecting Pit 30 s,the Atorvastatin group didn’t reduce the depress of J point,but the Nifedipine group and the combined group resisted J-point changes(P<0.05).After injecting pit 1 min,the Atorvastatin group and the Nifedipine group didn’t reduce the depress of J point,but the combined group decreased J-point changes(P<0.05).After injecting Pit 3,5,7 min,all reduced the variation(P>0.05).In comparing of the arrhythmogenesis rate of all groups,there were 6 rats(60%) in the control group,in the Atorvastatin group,the Nifedipine group and the combined group the arrhythmogenesis rate were accordingly 6(60%),2(20%) and 0.There’s no obvious difference between the administrated groups and the model group for the heart rate(P>0.05).Conclusion:Atorvastatin can evidently improve J-point changes of ECG of rats induced by Pit,but the addition of Atorvastatin to Nifedipine can better prevent coronary spasm,and decrease the arrhythmogenesis rate.
Keywords：AtorvastatinCoronary artery spasmRhoA/Rho kinase pathway
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 5-7 )