Clinical Analysis of Metastatic Non-small Cell Lung Cancer Mediastinal Lymph nodes

doi:10.14033/j.cnki.cfmr.2016.1.011

Abstract：Objective:To analyze of mediastinal lymph nodes metastasis of non-small cell lung cancer,and then discusse the reasonable surgical lymph node dissection.Method:The clinical data of 505 patients with non-small cell lung cancer who underwent lung resection and systematic lymph node dissection in Weifang People's Hospital from September 2010 to May 2015 were analyzed.There were 317 males and 188 females with an average age of 59.1 years old (39-77).There were 108 patients with left upper lobe tumor,86 patients with left lower lobe tumor,170 patients with right upper lobe tumor,27 patients with right middle lobe tumor and 114 patients with right lower lobe tumor.Subcarinal lymph node metastasis was observed in 118 patients(19.4%).There were 202 patients with squamous carcinoma,239 patients with adenocarcinoma and 64 patients with other types of carcinoma.The relationship of mediastinal lymph node metastasis with tumor location,patho-logical types and clinicopathological characteristics were analyzed.Result:There was statistical difference in mediastinal lymph node metastasis rate among different tumor locations(P=0.000).For patients with different pathological types,mediastina lymph node metastasis rate was the highest[56.5%(66/118)]in patients with adenocarcinoma.Mediastina lymph node metastasis rate increased with the increase in T staging,and patients with upper lobe tumor had a significantly higher mediastina lymph node metastasis rate than patients with tumors located in the middle or lower lobe of the left or right lung.Conclusion:Mediastina lymph node metastasis rate are lower in patients with left or right middle or lower lobe tumor,patients with squamous carcinoma whose clinical T staging is within T1.We can be appropriate to relax the surgery.