The Correlation between Infection in Patients with AECOPD,Serum TNF-α and CR3
TIAN Yu
Abstract：Objective:To explore the relationship between the level of serum TNF-α,neutrophil complement receptor 3(CR3),and bacterial infection in chronic obstructive pulmonary disease with acute exacerbation(AECOPD) patients.Method:60 AECOPD patients were divided into two groups according to sputum culture,25 cases in the positive group and 35 cases in the negative group.The serum TNF-αand CR3 was measured.Result:The level of the serum TNF-αand CR3 in the positive group was higher than the negative group,there was statistically difference in two groups(P<0.05).After treatment, the level of the serum TNF-αand CR3 in the positive group were showed a downwardtrend.After five weeks of treatment,there was no statistical difference in two groups(P>0.05).The serum TNF-α,CR3 positively related to the sputum culture positive group(P<0.05).The serum TNF-α,CR3 had no correlation with the negative group.Conclusion:The bacterial infection of AECOPD patients has a significant correlation with their TNF-α and CR3.
Keywords：Chronic obstructive pulmonary diseaseTumor necrosis factor-αNeutrophil complement receptor 3Bacterial infection
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 25-27 )