The Application of Patients with Organophosphorus Pesticide Poisoning in Mechanical Ventilation with Propofol and Dexmedetomidine in ICU
Abstract：Objective:To study the effect of sedative of Dexmedetomidine and Propofol in mechanical ventilation patients with organophosphorus pesticide poisoning in ICU.Method:56 patients of organophosphorus pesticide poisoning in mechanical ventilation were randomly divided into Dexmedetomidine group(28 cases) and Propofol group(28 cases).The HR,RR, SBP, DBP,Airway Pressure,Oxygenation index of patients were measured before treatment and after treatment,then the results were compared.Result:Effective sedation with Dexmedetomidine and Propofol were displayed in two groups,and airway pressure was reduced, heart rate and circulation were stabled,the HR,BP,RR and Oxygenation index were both changed significantly(P<0.05).The onset time in Propofol group was quickly than Dexmedetomidine group,the effect of sedation in Propofol group was more obvious than Dexmedetomidine group,the effect of respiratory depression was relatively small and the effect of lowering heart rate was more obvious in Dexmedetomidine group(P<0.05).Conclusion:Dexmedetomidine and Propofol are ideal sedative drugs in patients with organophosphorus pesticide poisoning with respiratory failure in mechanical ventilation in ICU.The onset time in Propofol are quickly than Dexmedetomidine,the effect of Sedation is more obvious.And the effect of respiratory depression is relatively small and the effect of lowering heart rate is more obvious in Dexmedetomidine.
Keywords：DexmedetomidinePropofolICUOrganophosphorus pesticide poisoningMechanical ventilation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3-6 )