Inhibitory Effects of Organophosphorus Pesticides on Acetylcholinesterase Activity
Abstract：Objective:To explore the inhibitory effects of organophosphorus pesticides on acetylcholinesterase activity.Method:In our hospital from January 2010 to December 2014 100 cases of organophosphorus pesticide poisoning patients were selected.For patients with after poisoning respectively 1,24,48,72,120 h and acetylcholinesterase activity were detected after cure.Comparison of patients cured after poisoning and acetylcholinesterase activity were analyzed.Result:1,24,48,72,120 h acetylcholinesterase in the blood of patients were significantly lower than that of the activity after poisoning after cure,there were significant difference(P<0.05).100 cases of poisoning patients in the emergency treatment, the mortality rate was 13%,the remaining patients transferred to the relevant department or hospital to continue treatment.Conclusion:Acute organophosphate poisoning patients,greatly inhibited acetylcholinesterase activity,leading to acetylcholine accumulation in brain tissue of patients, seriously affect the prognosis of patients,patients need timely effective treatment therefore,alleviate nerve tissue of patients with trauma,ensure completeness of patients with brain tissue.
Keywords：Organophosphorus pesticideAcetylcholinesterase activityInhibition
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 20-21 )