Curative Effect Analysis of Neonatal Hypoxic-ischemic Encephalopathy Treated with Ganglioside and Its Influence of Serum IL-23 and ;IL-17 Levels
Abstract：Objective:To explore the effect of Ganglioside in the treatment of neonatal hypoxic-ischemic encephalopathy(HIE) and the influence of interleukin-23(IL-23) and interleukin-17(IL-17) levels,thereby to provide the basis for application of ganglioside to treat HIE.Method:84 cases with HIE were randomly divided into the control group(n=42) and the observation group(n=42).The control group were treated with conventional therapy.On the basis of this,the observation group were administrated with Ganglioside.Total effective rate,reflection recovery time,muscle tonus recovery time,and consciousness recovery time were compared between the observation group and the control group.Serum was isolated before and after treatment,enzyme linked immunosorbent assay(ELISA) was then used to detect serum IL-23 and IL-17 levels.Result:In comparison with control group,a significant increase in total effective rate and a significant decrease in reflection recovery time,muscle tonus recovery time and consciousness recovery time in observation group.There were statistical significance(P<0.05).Serum IL-23 and IL-17 levels were lower after treatment than before treatment in two group (P<0.05).Moreover,Serum IL-23 and IL-17 levels were also significantly decreased after treatment in observation group when compared with same period in the control group(P<0.05).Conclusion:Treatment of HIE with Ganglioside has good curative effects.Inhibition of the IL-23/IL-17 inflammatory axis may be one of significant mechanisms by which Ganglioside treats HIE.
Keywords：Neonatal hypoxic-ischemic encephalopathyGangliosideInterleukin-23Interleukin-17
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1-2,3 )