Expression of PUMA in Laryngeal Squamous Cell Carcinoma and Clinical Significance
Abstract：Objective:To investigate the regulation of apoptosis factor P53 (P53 up-regulated modulator of apoptosis PUMA) and its relationship with the clinical expression in laryngeal squamous cell.Method: The expression of 35 cases of laryngeal squamous cell carcinoma PUMA normal tissues using immunohistochemical method, and clinical analysis of its relationship with clinicopathological features and prognosis.Result:The expression of PUMA protein in laryngeal squamous cell carcinoma was significantly lower than in normal tissue, were more significant between the two,(P<0.05); in laryngeal squamous cell PUMA with different clinical stages, histological grade, lymph node metastasis correlated.Conclusion:PUMA in laryngeal squamous cell carcinoma was low expression PUMA laryngeal squamous cell carcinoma positive expression group, the survival rate and survival time was significantly higher than the negative expression.
Keywords：Laryngeal SquamousPUMAImmunohistochemistryPrognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 4-5 )