Valuations of C-reaction Protein and Procalcitonin to Predict the Time Point of Weaning in Sepsis with Mechanical Ventilation
WANG Yu-e
YU Yuan
Abstract：Objective:To evaluate the predicted significance of C-reaction protein(CRP) and procalcitonin(PCT) in weaning outcome of patients with mechanical ventilation(MV) by the application of ROC curve.Method:112 ICU sepsis patients with mechanical ventilation were enrolled from October 2012 to August 2013 when the author was studying in the ICU of Peking Union Medical College Hospital.All patients met the clinical weaning criteria.Serum CRP and PCT levels were measured before weaning from MV.According to weaning outcome,all patients were divided into successful group and unsuccessful group,and the differences in levels of CRP and PCT were compared between the two groups.ROC curve for predicting weaning outcome was drawn to evaluate the prediction significance of serum CRP and PCT.Result:Serum levels of CRP and PCT before weaning in successful group were significantly lower than those of unsuccessful group(P<0.05),corresponding area under the curve(AUC) was 0.887(CRP) and 0.745(PCT),and Youden's index was 0.71(CRP) and 0.48(PCT).Below the level of 12.5 mg/L(CRP) and 3.55 μg/L(PCT),the success rate of weaning from MV was highest respectively.Conclusion:The serum CRP and PCT value before weaning have certain predictive values on weaning outcome,and can be used as screening indicator of weaning from MV in patients with sepsis.
Keywords：C-reaction proteinProcalcitoninSepsisWeaning from mechanical ventilationROC curve
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3-5 )