Treatment for Patients with Advanced Metastatic Castration Resistant Prostate Cancer by Using Zoledronic Acid Combined with Ketoconazole and Prednisone
Abstract：Objective:To evaluate the effect of Zoledronic Acid combined with Ketoconazole and Prednisone in the treatment of advanced metastatic castration resistant prostate cancer(mCRPC).Method:23 patients with advanced mCRPC were treated with Zoledronic Acid combined with Ketoconazole and Prednisone,PSA changes and degree of bone pain relieving were observed.Result:PSA decreasing occured in 13 cases(56.52%),the median effective time of PSA decreasing was 7.38 months.The significant efficiency of bone pain relieving occurred in 13 cases(56.52%),the median time was 7.53 months.The effective efficiency occurred in 8 cases(34.78%),the median effective time of PSA decreasing was 7.38 months.The inefficiency occurred in 2 cases(8.70%).No apparent side effect occuured in our study.Conclusion:The treatment for patients with advanced mCRPC with Zoledronic Acid combined with Ketoconazole and Prednisone can effectively relieve their urinary tract symptoms and bone pain,decrease generation of adverse bone events,inhance life quality and prolong survival time.
Keywords：Zoledronic acidKetoconazolePrednisoneBone metastasisProstate cancerProstate specific antigen First-author’s address:The People’s Hospital of Ganyu District of Lianyungang CityLianyungang 222100China
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 18-19,20 )