Investigation of Urate-lowering Therapy Effect on Blood Oxidative Stress in Hemodialysis Patients
Abstract：Objective:To investigate the improvement effect of urate-lowering therapy on blood oxidative stress in hemodialysis(HD) patients. Method:51 HD patients who had serum uric acid (SUA) levels above 480μmol/L in our hospital were selected as research objects,the mean age was (51.3±4.9)years,the mean HD duration was (3.7±0.8)years,the mean dialysis time per week was (11.6±0.9)hours.Blood samples were collected for detecting SUA and oxidative stress markers(8-OhdG and 3-NT) before and after the treatment.Result:After urate-lowering therapy,the level of SUA in HD patients decreased significantly(P<0.01),comparing with the baseline level (512.4±109.8)μmol/L.The oxidative stress markers 8-hydroxy deoxyguanosine (8-OhdG ) also decreased significantly,comparing with the baseline level [(1.93±0.94)ng/ml vs (0.97±0.43)ng/ml,P<0.01],which were positively correlated with the level of SUA,the correlation coefficient was 0.608,P<0.01.However,the 3-nitrotyrosine modified protein (3-NT) was not significantly different from its baseline level [(32.46±9.95)nM vs (29.23±9.63)nM,P=0.104].Conclusion:Urate-lowering therapy can ameliorate the oxidative stress status in HD patients,is worthy of clinical application.
Keywords：End-stage renal diseaseHemodialysisHyperuricemiaOxidative stress
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1-2 )