Expression and Clinical Significance of Thrombospodin-1 and Its Receptor CD36 in Neonatus with Bronchopulmonary Dysplasia
Abstract：Objective:To investigate the expression and clinical significance of thrombospodin-1 (TSP-1) and its receptor CD36 in bronchopulmonary dysplasia (BPD) children serum and bronchoalveolar lavage fluid.Method:The expression of TSP-1 and CD36 in serum and bronchoalveolar lavage fluid of BPD children(n=45) and non-BPD neonatus(n=32) were detected by ELISA.Correlations of TSP-1 and CD36 levels and the comparisons between groups were analyzed respectively.Result:The expression of TSP-1 and CD36 in serum and bronchoalveolar lavage fluid of BPD children were significantly higher than those of non-BPD neonates respectively(P<0.05).There was a positive correlation relationship between the expression of TSP-1 and CD36 in serum and bronchoalveolar lavage fluid(P<0.05).Conclusion:TSP-1 and CD36 may play a role in the pathogenesis of neonatus BPD and act cooperatively through an unexplored mechanism,the specific mechanism needs further study.
Keywords：Thrombospodin-1CD36Bronchopulmonary dysplasiaELISA
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3-5 )