A Correlation Study between the CTLA-4 at Exon 49 Single Nucleotide Polymorphisms and Myasthenia Gravis
PENG Zhong-wei
LIU Zhao-ji
ZHENG Wei-hong
Abstract：Objective:To investigate the relevance of CTLA-4 exon region 49A/G single nucleotide polymorphisms and myasthenia gravis patients in Fujian province.Method:The CTLA-4 gene exon 1 region+49A/G polymorphism of myasthenia gravis patients in Fujian area were detected by PCR amplification and restriction fragment length polymorphism method.Result:There were no significant differences between the MG group and the control group in 49A/G locus allele and genotype,and there was no significant connection between MG and CTLA-4 exon 49 single nucleotide polymorphisms in myasthenia gravis patients(P>0.05).The frequency of GG genotype in male patients with MG was significantly higher than female patients(χ2GG=4.41, P=0.04).Conclusion:MG may be not correlated with the haplotype and genotype of CTLA-4 at exon 49 in Fujian area.
Keywords：Myasthenia gravisCytotoxic T lymphocyte associated antigen-4Gene polymorphisms
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 17-19,20 )