The Expression and Clinical Significance of Hypoxia-inducible Factor-1α in Salivary Adenoid Cystic Carcinoma
SUN Qiao-mei
LIN Yu-jing
Abstract：Objective:To investigate the expression and clinical significance of hypoxia-inducible factor-1α(HIF-1α) in salivary adenoid cystic carcinoma(SACC).Method:Immunohistochemistry method was used.HIF-1α in 45 cases of salivary adenoid cystic carcinoma,45 cases of pleomorphic adenoma and 45 cases of normal salivary gland tissue were detected.Result:The positive expression rate of HIF-1α in normal salivary gland tissue,pleomorphic adenoma and ACC increased in turn,the difference between the groups was statistically significant(P<0.05).HIF-1α in transfer group was dramatically higher than that in non-metastatic group,in nerve invasion group was higher than that in non-infringement group(P<0.05).Conclusion:HIF-1α can be an important indicator of ACC diagnosis,invasion,metastasis and prognosis.
Keywords：Adenoid cystic carcinomaHypoxia-inducible factor-1α
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 7-8 )