The Clinical Analysis of 30 Cases of Brucellosis

Abstract：Objective:To investigate the epidemiological,clinical,laboratory and treatment data of brucellosis in Xuzhou.Method:The prevalence, symptoms and signs,laboratory,treatment and outcome data of 30 brucellosis patients admitted in affiliated hospital of Xuzhou Medical College from January 2011 to July 2014 were retrospectively analyzed.Result:The cases of brucellosis were increased gradually in Xuzhou,which were more frequent in winter and spring.The patients were mainly middle-aged males,and most of them had a history of close contact with sheep.The main clinical manifestations were fever(100%), arthralgia(73.3%),sweating(53.3%) and fatigue (40.0%).Some patients had myalgia(26.7%),sepsis(16.7%),pneumonia(13.3%),hepatomegaly and splenomegaly(10.0%),pleural effusion(10.0%) and rash(6.7%).Only 11 cases(36.7%) had the typical abortus fever.Blood routine and liver functions were normal in most patients,while ESR was increased in 23 cases(76.7%),and osteoarthropathy was comfirmed by radiograph in 8 cases(36.4%).Only 2 cases were confirmed the diagnosis during the first visit.The combinational treatment with Doxycycline,Rifampin and Levofloxacin were effective,with the result that 27 cases had their fever dropped to normal in 2 weeks.Conclusion:Sporadic cases of brucellosis in Xuzhou increas gradually in recent years,which usually have atypical clinical manifestations.Epidemiological clues should be kept in mind in order to avoid misdiagnosis.The combinational therapy of Doxycycline,Rifampin and Levofloxacin are effective against brucellosis.