The Clinical Observation of Trimetazidine in the Treatment of 78 Elderly Patients with Coronary Heart Disease

WANG Hai-jun; FAN Xiu-hua

Abstract：Objective:To investigate the clinical efficacy of Trimetazidine in the treatment of elderly patients with coronary heart disease,and compare with the clinical efficacy of Isosorbide Mononitrate Tablets,in order to provide basis for clinical treatment of senile coronary heart disease.Method:90 patients who consistent with the diagnosis of chronic stable angina standard admitted to our hospital from January 2009 to January 2011 were selected,they were divided into the Trimetazidine group and the Isosorbide Dinitrate Tablet group according to the random number table method,45 cases in each group.On the basis of conventional therapy,the Trimetazidine group was given Trimetazidine Dihydrochloride Tablets for treatment,the Isosorbide Dinitrate Tablet group was given Isosorbide Mononitrate Tablets for treatment,a treatment course was 3 month.After 3 months of treatment,the data of angina pectoris attack time,frequency and ECG changes in the two groups were statistically analyzed,the clinical effect and electrocardiogram efficacy between the two groups were observed and compared. Result:After treatment,the total effective rate of Trimetazidine group was 82.22%,it was significantly higher than 57.78%of Isosorbide Dinitrate Tablet group, and the total effective rate of electrocardiogram in Trimetazidine group was 77.78%,it was significantly higher than 51.11%of Isosorbide Dinitrate Tablet group, the differences were statistically significant(P<0.05).The two groups were no adverse reaction during the treatment period.Conclusion:Trimetazidine is a new type of treatment of senile coronary heart disease,its curative effect is obviously superior to the traditional drug treatment,is a new choice for clinical treatment of senile coronary heart disease medication,is worthy of clinical widely promotion.