The Comparison of Clinical Effect of Decitabine Plus Cisplatin and Gemcitabine Plus Nedaplatin in the Treatment of Recurrent Metastatic Breast Cancer

LI Wei-zhan; ZENG Wei-hua; CAO Xiao-long

Abstract：Objective:To study the clinical effects of Decitabine plus Cisplatin and Gemcitabine plus Nedaplatin in the treatment of recurrent metastatic breast cancer.Method:The clinical data of 70 patients with recurrent metastatic breast cancer admitted to our hospital from January 2008 to January 2014 were retrospectively analyzed.According to the different treatment of patients,they were randomly divided into the experimental group and the control group, 35 cases in each group.The experimental group was treated with Decitabine plus Cisplatin,and the control group was treated with Gemcitabine plus Nedaplatin. The clinical effect and adverse reaction after four courses between the two groups were observed and compared.Result:After the four courses,the total effective rate of experimental group was 48.57%,and the total effective rate of control group was 45.71%,there was no statistically significant difference in total effective rate between the two groups(P>0.05).Two cases occurred decrease of white blood cells inⅢdegree,1 case occurredⅢdegree thrombocytopenia,1 case occurredⅠdegree renal injury,six cases occurredⅡdegree renal injury and nineteen cases occurred gastrointestinal tract reaction in the experimental group.In the control group,1 case occurred decrease of white blood cells inⅢdegree,two cases occurredⅠdegree renal injury,nobody occurredⅡdegree renal injury,and two cases occurred gastrointestinal tract reaction.TheⅡdegree renal injury and gastrointestinal tract reaction of experimental group were significantly higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion:The clinical effects of Decitabine plus Cisplatin and Gemcitabine plus Nedaplatin in the treatment of recurrent metastatic breast cancer are equivalent,is worth in clinical promotion.