The Analysis of Pathogenic Bacteria of Neonatal Ventilator-associated Pneumonia

CHEN Yang; CUI Xiang-jun

Abstract：Objective:To investigate the analysis of pathogenic bacteria of neonatal ventilator-associated pneumonia,and provide reference for clinical diagnosis and treatment.Method:57 children with VAP using mechanical ventilation time≥48h admitted to our hospital from July 2011 to March 2014 were selected,lower respiratory tract secretions were extracted,made pathogenic microorganism culture and drug sensitive test,analyzed the distribution of pathogens and antibiotic sensitive rate of specimens.Result:61 pathogenic bacteria were detected,including gram negative bacteria accounted for 88.52%,gram positive bacteria accounted for 4.92%,the difference was statistically significant in the detection rate between two kinds of bacteria(P<0.05),other fungi accounted for 6.56%.The predominant pathogenic bacteria were gram negative bacterium:Klebsiella pneumoniae (24.59%),Escherichia coli (19.67%),Enterobacter cloacae (14.75%),Acinetobacter baumannii coli (13.11%).Four main gram negative bacterium (Klebsiella pneumoniae,Escherichia coli,Enterobacter cloacae, Acinetobacter baumannii) to Amikacin,ciprofloxacin and imipenem sensitive rate were 79.55%,77.27%,86.36%,had high sensitivity,lower susceptibility to cephalosporins.Conclusion:The neonatal ventilator associated pneumonia pathogen mainly gram-negative bacteria,clinical treatment of neonatal VAP should be based on the distribution of pathogens and their antibiotic resistance characteristics of each region,using antibiotics reasonably and effectively.