Effects of Different Doses of Atorvastatin on Lipid Lowering Efficacy Observation of Heterozygous Familial Hypercholesterolemia

BU Jian-xin

Abstract：Objective:To investigate the lipid-lowering effect of Atorvastatin on heterozygous familial hypercholesterolemia(familial hypercholesterolemia,FH).Method:68 cases with heterozygous FH,were randomly divided into the observation group(n=34) and the control group(n=34).The observation group was given Atorvastatin tablets 60 mg,the control group was given Atorvastatin tablets 40 mg,detection of total cholesterol in each dosage group fasting peripheral blood(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C), efficacy was compared before and after treatment.Result:After one course of treatment,the observation group TC,HLD-C,LDL-C were (5.12±0.64) mmol/L,(1.25±0.02)mmol/L,(3.13 ±0.48)mmol/L,compared with before treatment,there were statistical significance(t=2.898,P<0.05;t=1.762,P<0.05;t=2.954,P<0.05).The control group after administration of TC,HLD-C,LDL-C were (7.34±0.32)mmol/L,(1.13±0.21)mmol/L, (4.06±0.21)mmol/L,compared with before treatment,there were statistical significance(t=1.958,P<0.05;t=1.926,P<0.05;t=1.968,P<0.05). The comparison between two groups,the observation group TC,LDL-C,HDL-C decreased significantly than that in the control group,with statistical significance(P<0.05).The total clinical effective rate of the observation group was 91.18%(31/34),the total clinical effective rate of the control group was 82.35%(28/34),there was statistically significant difference between two groups(χ2=3.968,P<0.05).Conclusion:The ideal lipid-lowering effect of Atorvastatin 60 mg/d dose of FH heterozygotes,is worthy of clinical application.