Effect of Dexmedetomidine on Recovery Process in Pediatric Anesthesia Undergoing Tonsil Removal Surgery

LI Wen-jing; HU Yi-ping; DING Jiu-hong

Abstract：Objective:To investigate the effect of Dexmedetomidine on recovery process in pediatric anesthesia undergoing tonsil removal surgery. Method:30 patients withⅠtoⅡof ASA physical status,4 to 12 years for radical operations of tonsil removal,were randomly assigned into 2 groups. Patients in the dexmedetomidine group(GroupⅠ,n=15) received an infusion in 10 minutes of Dexmedetomidine 1μg/kg before anesthesia induction and then an infusion of 0.7μg/(kg·h) for maintenance.Patients in the control group(GroupⅡ,n=15) received the same rate and volume of normal saline by infusion.Anesthesia induction was performed using Propofol 2.5 mg/kg,Fentanyl 0.002-0.003 mg/kg,Cis-atracurium 0.1 mg/kg for both GroupⅠand GroupⅡ.Intraoperative Propofol and Remifentanil,Cis-atracurium to maintain anesthesia for both groups.Mean blood pressure(MBP),heart rate(HR), timing of extubation,time of staying in the PACU,adverse effects when awake and suction(T0),extubation time(T1),after extubation 5 min(T2), entering PACU(T3) and out of PACU(T4) were measured and recorded.Result:Comparing with Group Ⅱ,Group Ⅰexperienced less haemodynamic fluctuation(MBP and HR)(P<0.05) at T0 and T1,and lower incidence of pain and restlessness(P<0.05) at T2.There was not statistically significant in MBP and HR between two groups at other time.Comparing with Group Ⅱ,Group Ⅰ experienced lower incidence of pain,restlessness and anxiety(P<0.05). Extubation time,staying in the PACU time,the incidence of vomiting,lethargy incidence difference was no statistically significant between two groups(P>0.05).Conclusion:Dexmedetomidine as an adjunct to general anesthesia for pediatric patients undergoing tonsil removal surgery can keep stable haemodynamics,minimize adverse effects during recovery process.