Clinicopathological Analysis of Central Neurocytoma

Abstract：Objective:To study the clinicopathological features,immunophenotype and differential diagnoses of central neurocytoma(CNC) so as to further realize the tumor and avoid misdiagnosis.Method:Clinical manifestations,radiological,histological characteristics and immunophenotype were analyzed in 10 cases of CNC.Result:5 male and 5 female patients,with ages ranging from 9 to 45 years(mean age 27.5 years),and all tumors were located in the ventricular system.Histologically,the tumor were composed of small uniform round cells.These tumor cells with clear cytoplasm and perinuclear halo were arranged in rosettes pattern and honeycomb pattern.The most dominant feature of CNC was the cell-free island of neuropil matrix.Immunohistochemically,10 cases were positive for NeuN and Syn,9 cases were positive for NSE,1 case was partly positive for GFAP,10 cases were negative for NF and CgA.The positive index of Ki-67 was very low in all cases,with less than 2%of the nuclei labeled.Surgical resection was the primary therapy of CNC.No recurrence were seen in the 10 patients followed-up.Conclusion:CNC is a rare tumor with neuronal differentiation.Surgical resection is the primary therapy,CNC has a benign prognosis. in general. Immunohistochemistry is very important for the diagnosis and differential diagnoses of CNC.