Correlation of Serum IGF-1 and IGFBP-1 Detection with Pregnancy Outcomes of Pregnant Women

WANG Qiong-hua; YAN-Yu

Abstract：Objective:To investigate the correlation of serum insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-1(IGFBP-1) detection with the pregnancy outcomes of pregnant women.Method:A total of 121 pregnant women receiving examination in our hospital from August 2011 to August 2013 were randomly selected as subjects,with 61 outcomes good women as the observation group and 60 outcomes bad women as the control group. Radioimmunoassay was used to detect the level of serum IGF-1 and IGFBP-1 for further analysis on the correlation of serum IGF-1 and IGFBP-1 with pregnancy outcomes.Result:The IGF-1 and IGFBP-1 of the observation group and control group both showed negative linear correlation.The neonatal height and weight of two groups both showed positive correlation with IGF-1 level.The IGFBP-1 level showed negative correlation with neonatal height and weight.IGF-1 positive rate of placenta in the observation group was 90.16%,the control group was 75.00%.Conclusion:The neonatal height and weight are both positively correlated with IGF-1 level. The IGFBP-1 level is negatively correlated with neonatal weight and height.As early signals of fetus,IGF-1 and IGFBP-1 can be adopted as important predictive indicators for pregnancy.