Effect of Deliberate Hypotension of Dexmedetomidine on Inflammatory Factors in Patients Undergoing Surgery for Endoscopic Sinus Surgery

JIANG Xue-run

Abstract：Objective:To investigate the effects of deliberate hypotension of dexmedetomidine on inflammatory factors in patients undergoing endoscopic sinus surgery.Method:Eighty ASA Ⅰor Ⅱpatients scheduled for elective endoscopic sinus surgery were randomly divided into blank group(group C) and dexmedetomidine group(group D),each group of 40 cases.Group D was given continual intravenous injection of dexmedetomidine(1.0μg/kg) at 30 minutes before induction of anesthesia,followed by infusion of dexmedetomidine[0.5μg/(kg·h)] until the end of surgery.Group C was given an equal volume of normal saline. Heart rate(HR),mean arterial pressure(MAP) were determined 30 minutes before anesthesia induction(T0),immediately after induction(T1),immediately after extubation(T2).The cervical venous blood samples were obtained from the patient at 30 minutes before anesthesia induction (T0),when endotracheal tube was removed (T2) and 2 h(T3),6 h(T4),12 h(T5),24 h(T6) post operation for determination of the expression of CPR,IL-6 and TNF-α.Result:The difference of the general situation and the monitoring indicators of intraoperative between the patients of the two groups was not statistically significant(P>0.05).Compared with group C,CPR,IL-6 and TNF-αof group D were all lower at each time point of T2-T6,difference was statistically significant (P<0.05).Compared with T0,CPR of group C was began to rise from T3,IL-6 and TNF-αof group C were began to rise from T2,and rosen to the highest at T4,began to decline at T5;CPR of group D was began to rise from T4,IL-6 and TNF-αof D group were began to rise from T3,and rosen to the highest at T4,began to decline at T5,difference was statistically significant (P<0.05).Conclusion:Deliberate hypotension of dexmedetomidine in patients undergoing endoscopic sinus surgery is safe and feasible and can reduce inflammation and postoperative infection.