Diagnostic Value of Retinol Binding Protein,Cystatin C andβ2 Microglobulin in Type 2 Diabetes Mellitus Early Renal Damage
SU Wen-tang
LIU Jing
Abstract：Objective:To study the diagnostic value of srum retinol binding protein(RBP),cystatin C(Cys C) andβ2 microglobulin(β2-MG) in early renal damage.Method:125 case of T2DM were selected.The urinary albumin excretion rate(UAER) of 62 Patients with T2DM was less than 20μg/min was normal albuminuria group,the UAER of 63 patients with T2DM was situated between 20μg/min and 200μg/min was microalbuminuria group.45 cases of healthy people was control group.RBP was tested by the immune turbidimetric method,Cys C andβ2-MG were test by particle enhanced immuno turbidimetric assay. Result:The content and the positive rate of RBP,Cys C,β2-MG、ureaand creatinine in microalbuminuria group were higher than other two groups(P<0.05).The Content and the positive rate of RBP,Cys C,β2-MG in normal albuminuria group were higher than control group(P<0.05).The positive rate of RBP and Cys C was higher than RBP or Cys C(P<0.05).The positive rate of RBP,Cys C orβ2-MG in the two experimental group were higher than Urea or Crea(P<0.05).The positive rate of RBP,Cys C andβ2-MG in the two experimental group were higher than RBP and Cys C(P<0.05).Conclusion:RBP,Cys C andβ2-MG can be used as marker in diagnosis type 2 diabetes mellitus early renal damage,the clinical value of combined detection is greater.
Keywords：Retinol binding proteinCystatin Cβ2 microglobulinType 2 diabetes mellitusEarly renal damage
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 41-42,43 )