Influence of Pioglitazone Combined with Intervention of Life Style on Metabolic Syndrome and the Sensitivity of Insulin

XU Min-gang

Abstract：Objective:To observe the influence of pioglitazone combined with intervention of life style on metabolic syndrome and the sensitivity of insulin. Method:38 cases of patients with metabolic syndrome were treated from 2010 to 2013 in author’s hospital,Were randomly divided into control group (18 cases) and observation group (20 cases),the control groupusing individual lifestyle intervention,namely through the patient’s diet and lifestyle interventions to treat, intervention study group:the use of pioglitazone combined with lifestyle,which in addition to the patient’s diet and life ways to intervene,and pioglitazone 30 days. Observe the patient’s blood pressure and waist circumference,fasting blood glucose,high density lipoprotein cholesterol,blood Three triacylglycerol,insulin sensitivity index and plasma insulin.Result:After treatment,the observation group systolic and diastolic blood pressure,blood triacylglycerol,fasting glucose and plasma insulin was significantly lower than the control group,the difference was statistically significant(P<0.05).But the observation group the insulin sensitivity index was significantly higher than the control group,the difference was statistically significant(P<0.05).Conclusion:The treatment of pioglitazone combined with intervention of life style on metabolic syndrome may improve many metabolic abnormality,and raise the sensitivity index of insulin.