Preeclampsia Patients with Placenta HIF-1αand IL-6 Expression Differences for Fetal Development Impact Analysis
QIN Yi-wei
Abstract：Objective:To study the oxygen inhibition factor HIF-1αand IL-6 in the pathogenesis of preeclampsia and affect fetal development. Method:Including full line elective cesarean delivery of healthy pregnant women 40 cases as normal control group,preeclampsia,40 cases of normal pregnant women and fetal development as PE group,pre-eclampsia and fetal growth restriction(FGR) 40 cases of pregnant women as PE+FGR group.Using real-time quantitative PCR(realtime-PCR) technology and protein imprinting method(WB) groups of pregnant women in the placenta tissue HIF-1α and IL-6 mRNA and protein expression.Result:HIF-1αand IL-6 mRNA and protein expression:PE and PE+FGR group compared with normal control group,and extremely significant difference was statistically significant(P<0.01).But PE and PE+FGR group of HIF-1α and IL-6 mRNA and protein expression,in contrast,a significant difference,with statistical significance(P<0.05).Conclusion:The placental HIF-1αand IL-6 for leading to the onset of preeclampsia and normal development of the fetus plays an important role,for the diagnosis and treatment of preeclampsia provides relevant countermeasure.
Keywords：PreeclampsiaPlacentaHIF-1αIL-6
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1-3 )