Evaluation of Superoxide Dismutase and Cystatin C in the Early Diagnosis of Diabetic Nephropathy in Type 2 Diabetes Mellitus

Abstract：Objective:To compare the changes of serum of 136 cases of patients with type 2 diabetes mellitus SOD activity and CysC,Cr concentration, to explore the value of SOD activity and CysC concentration in the diagnosis of early renal damage in patients with type 2 diabetes mellitus.Method:136 cases of type 2 diabetes mellitus patients with urinary albumin excretion rate(UAER) were divided into normal albuminuria group,micro albuminuria group,macro albuminuria group.And the concentration of serum SOD activity was detected,CysC and Cr,index and to compare the differences between three groups. Result:The concentration of Cr of macro albuminuria group was (213.64±44.33)μmol/L,was significantly higher than that in normal albuminuria group,and the difference of micro albuminuria group and normal albuminuria group was no statistical significance.Macro albuminuria group,micro albuminuria group,SOD activity,CysC concentration was (57.10±10.73)IU/ml,(94.36±14.31)IU/ml;(3.97±1.14)mg/L,(2.26±0.65)mg/L.Compared with the normal albuminuria group were significantly increased,which macro albuminuria group increased more obviously.Conclusion:The concentration of Cr in vivo changes in patients with diabetic nephropathy SOD activity and serum CysC concentration is positively correlated with serum,to illustrate its important value in reflecting renal function damage,and change time is Cr earlier,the renal damage in patients with SOD activity and serum CysC concentration than the significance of early diagnosis of Cr is more than Cr,and sensitive.