Effects on Urinary Albumin Excretion Rate of Early Diabetic Nephropathy in Patients with ACEI and ARB Spironolactone in Combination
YE Jian-zhen
XIE Lin
YU Ai-hong
Abstract：Objective:To investigate Spironolactone and ACEI and ARB combined impact of early diabetic nephropathy and urinary albumin excretion rate applications.Method:From January 2013 to January 2014 in our hospital for treatment of 78 patients were randomly divided into the control group and the treatment group.The control group was given ACEI and ARB combination therapy for treatment,on the basis of the control group the treatment group was given Spironolactone treatment,after 2 months of treatment,patients were observed plasma albumin(Alb),urinary albumin excretion rate(UAER),creatinine(SCr), and electrolyte changes.Result:After treatment,the UAER of two groups were lower,but the treatment group was lower than the control group,the difference was significant(P<0.05).Alb,SCr and electrolyte changes of the two groups were not significant,the difference was not statistically significant(P>0.05). Conclusion:Spironolactone combination with ACEI and ARB treatment of early diabetic nephropathy,urinary albumin excretion rate is significantly lower,with better clinical results and should be introduced in clinical practice.
Keywords：SpironolactoneACEIARBDiabetesUAER
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 15-16 )