Investigation the Influences of Budesonide Inhalation on CD4+CD25+ Regulatory T Cells Ratio and Serum IL-4,IFN-γ Concentration of Asthmatic Children
LI Sheng-jun
LI Jun-xin
XUE Ai-guo
Abstract：Objective:To investigate the influences of Budesonide inhalation on ratio of regulatory T cells in blood and serum IL-4,IFN-γconcentration of asthmatic children.Method: 40 asthmatic children were randomly divided into control group and treatment group. Based on the basic treatment as control group, the treatment group was also given Budesonide inhalation. Flow cytometry was used to detect the Treg ratio in PBMCs. ELISA was used to detect the concentration of IL-4,IFN-γ in serum.Result: The changes of Treg ratio and IFN-γconcentration were significantly increased and the IL-4 concentration was significantly decreased after treatment of the two groups(P<0.05). The difference of Treg ratio, IFN-γconcentration and IL-4 concentration between the two groups after treatment were all significantly significant(P<0.05).Conclusion: Budesonide inhalation can treat asthmatic patients effectively, probably by advancing the number of Treg cells and improving dynamic equilibrium between Th1 and Th2.
Keywords：BudesonideAsthmaCD4+CD25+ regulatory T cellsIL-4IFN-γ
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 18-19 )