Clinical Observation of Tissue Engineering Collagen Dermal Substitute to Repair the Wound

Abstract：Objective:To observe and analyze the clinical effect of using tissue engineering collagen dermal substitute to repair the wound, investigating the best method for clinical wound repair.Method:From October 2010 to October 2012 in our hospital 24 cases of critically ill patients withhigh-risk bedsore, in accordance with the hospitalization order and wound type patients were randomly divided into observation group and control group, 12 cases in each.The control group were treated with vaseline gauze to cover the wound, the observation group were treated with tissue engineering collagen membrane to cover the wound, all wrapped and fixed in patients using conventional techniques, clinical treatment effects were compared between the two groups of patients.Result:Observation group of patients with complete healing time is shorter than the control group, the healing quality is better than that of control group, the difference was statistically significant (P<0.05). Two groups of patients with critical organs such as heart, kidney, liver and lung function were performed well, there was no significant difference. Control group with 1 case (8.33%) patients experienced the original wound contracture, 7 cases (58.33%) patients experienced obvious scar hyperplasia; Observation group no adverse reaction.Conclusion:Tissue engineering collagen sea mask as a new dermal substitutes used in wound repair in patients, efficacy, safety and good biological compatibility, no rejection of the body, it has a broad development prospect in clinical treatment in critically ill patients with bedsore in Department of neurosurgery.