The Association of MICA Polymorphism of Fifth Exon with Latent Autoimmune Diabetes in Adults
LIU Jun-ying
YAN De-wen
WANG Ji-guo
Abstract：Objective:To investigate the correlation situation of the MICA polymorphism of fifth exon and late onset autoimmune diabetes in adult(LADA). Method:Thirty-three cases of LADA patients(LADA group) from May 2010 to August 2013,35 patients with type 2 diabetes(T2DM group) and 40 cases of normal controls(NC group) were selected. The three groups in MICA exon 5 polymorphism difference were observed and compared. Result:Gene MICA fifth exon A5.1 promoter allele frequency in LADA group was significantly higher than NC group(P<0.05),while the other allele distribution had no significant difference between NC group and LADA group(P>0.05). Gene MICA fifth exon A5.1 promoter allele frequency in T2DM group was no significantly difference with NC group(P>0.05). Conclusion:LADA patients with gene MICA exon 5 polymorphism are different with normal people,the allele A5.1 and LADA disease are closely related,which is an important risk factor of LADA and can be regarded as a genetic marker in LADA.
Keywords：Adult late onset autoimmune diabetesMICA geneFifth exon
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 36-37 )