The Value of First Trimester Screening with Ultrasound in the Detection of Nerve System Malformation

ZHOU Xue; WANG Chun-lian; LI Zheng-bin

Abstract：Objective:To evaluate the value of first trimester screening with ultrasound in the detection of nerve system malformation.Method:3492 pregnant women undergoing first trimester screening with ultrasound from January 2011 to April 2013 were enrolled in this study.The pregnancy outcome was recorded,11-13+6 weeks fetal was given ultrasound system,in addition to the measurement of fetal crown-rump length,fetal crown-rump length,NT and venous catheters detection.Nerve system malformation was screened in accordance with the standards of the mid-trimester ultrasound section.The fetuses with major abnormalities were terminated according the choice of the parents after consultation.Result:Among the 3492 fetuses,10(0.29%) fetuses were diagnosed with nerve system malformations,including 9 fetuses with anencephaly and spina bifida,1 fetuses with full forebrain 4(0.11%) fetuses were diagnosed with nerve system malformations in the first trimester,including 2 cases with arachnoid cyst,1 case with hydrocephalus,1 case of lateral ventricle dilatation.Conclusion:Although the first trimester (11-13+6 weeeks) screening with ultrasound could detect the fetuses with major malformations,it can not replace the second trimester screening. Take two kinds of inspection together can screen for fetal nervous system malformations better.