The Clinical Significance of Combined Detection of Down’s Screening and Free Fetal DNA Investigation
SUN Hong-yue
YUAN Lu
XU Guang-li
Abstract：Objective:To investigate the clinical significance of combined detection of the interim of Down’s screening in pregnant women and blood free fetal DNA screening. Method:Pregnant women in 15-20+6 weeks were test of Down’s syndrome by time resolved immunofluorescence. High-risk groups were further tested of free fetal DNA from mother’s blood by gene sequencing.Result:10 065 pregnant women received Down’s screening,and 752 cases were estimated to be high-risk.At last 678 cases received the fetal DNA gene sequencing.14 cases were confirm chromosome abnormalities,including 10 number abnormal and 4 cases of structure abnormalities.The total 14 cases were detected of chromosome analysis from amniotic fluid cells,the other 676 cases were followed up,the results showed that two cases were not according with the NDA investigation,the total accuracy rate was 99.7%(676/678).Conclusion:Combined detection of Down’s screening and mother blood free fetal DNA test is effective in reducing the birth defects.
Keywords：Down’s screeningFree fetal DNA screeningCombined detection
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 57-57,58 )