Plasminogen Activator Inhibitor-1 and Its Gene Expression and Significance of the Promoter Region of 4G/5G Polymorphism in Colorectal Cancer and Noncancerous Tissues
CAI Fen
Abstract：Objective:To investigate the plasminogen activator inhibitor-1 (PAI-1) and the promoter of a guanine sub region of the insertion/deletion polymorphism (4G/5G) relationship with the occurrence and development of colorectal cancer.Method:Using PCR technique and agarose gel electrophoresis of PAI-l gene 4G/5G polymorphism detection to analyze 30 cases of colorectal cancer colorectal cancer tissue and adjacent normal colorectal tissues,and compare them.Using enzyme-linked immunosorbent method to detect the contents of the specimen organization PAI-1.Result:No significant expression of PAI-1 of three gene in patients with colorectal cancer in colorectal cancer tissues and adjacent normal colorectal tissue differences(P>0.05);tissue PAI-1 content was high expressed in patients with colorectal cancer(P<0.05).Conclusion:The high expression of PAI-1 is related to the transfer of colorectal cancer,but PAI-1 gene polymorphism is not related to the transfer of colorectal cancer.
Keywords：Colorectal cancerPlasminogen activator inhibitor-1Gene frequencyPolymorphism
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 49-50,51 )