A Correlation Study of 15-PGDH,COX-2 Protein in Gastric Carcinogenesis
LUO Xiao-xia
Abstract：Objective:To detection the 15-PGDH,cyclooxygenase-2(COX-2) expression in gastric cancer tissues,15-PGDH,cyclooxygenase-2(COX-2) in the process of gastric cancer formation mechanism.Method:Immunohistochemical method in 165 cases of gastric carcinoma and 87 cases of normal gastric mucosa 15-PGDH,cyclooxygenase-2(COX-2) expression.Result:The gastric cancer 15-PGDH,cyclooxygenase-2 (COX-2) positive expression rate was 13.94%(23/165) and 78.18%(129/165).Normal gastric mucosa 15-PGDH,cyclooxygenase-2(COX-2) positive expression rate was 63.22%(55/87),25.29%(22/87);15-PGDH in gastric cancer,cyclooxygenase-2(COX-2) expression and the degree of tumor differentiation,TNM stage and lymph node metastasis(P<0.05),the positive expression of COX-2 related(P<0.05),inversely correlated with 15-PGDH expression(P<0.05).Conclusion:15-PGDH,cyclooxygenase-2 (COX-2) expression and the biological behavior of gastric carcinoma are significantly correlated,15-PGDH and cyclooxygenase-2(COX-2) expression in gastric cancer tissue infiltration determining to metastasis and prognosis.
Keywords：Gastric carcinomaImmunohistochemistry15-PGDHCyclooxygenase-2
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 59-60 )