Study the Clinical Application of Anti-CCP Antibody in Diagnosis of Rheumatoid Arthritis

HU Zhuang-bin

Abstract：Objective:To investigate the clinical application value of anti-cyclic levels in diagnosis of patients with rheumatoid arthritis.Method:Selected 80 patients with rheumatoid arthritis,80 patients with other kinds of connective tissue disease,and 80 cases of healthy people accepted medical examination at the same period for the study.Enzyme-linked immunosorbent method of three groups of serum anti CCP antibody were tested,and tested the IgM-RF positive expression rate of patients with rheumatoid arthritis and other category connective disease patients and healthy people,and calculated the CCP antibody specificity in the process of rheumatoid arthritis diagnosis.Result:Compared to patients with other kinds of connective tissue disease and cases of healthy people,the CCP antibody positive expression rate of rheumatoid arthritis patients was significantly higher(P<0.05);In 80 cases of healthy people,78 cases of anti CCP antibody testing was true negative,2 cases of false positives,anti-CCP antibodies specificity of 97.5%;The rate of false positives of healthy people was 2.5%,significantly lower than the IgM-RF false positive rate for 21.3%,the differences were statistically significant (P<0.05).Conclusion:In the process of diagnosis of rheumatoid arthritis,anti-CCP antibody specificity is extremely high,the titer in patients with other connective tissue diseases as well as a significantly higher compared to healthy subjects,with a high clinical value.