The Changes and Significance of Homocysteine,Cystatin C and CRP Level in the Serum of Patients with Gestational Diabetes Mellitus

FENG You-jian; ZHANG Ying

Abstract：Objective:To explore the changes of homocysteine(Hcy),cystatin C(CysC) and CRP level in the serum of gestational diabetes mellitus patients(GDM),and the relationship between the changes of that and islet function.Method:A total of 240 cases with GDM diagnosed by outpatient from January to December in 2012 were selected as an observation group,and 100 healthy pregnant women in the same period as a control group were selected.Levels of Hcy, CysC,CRP,FBG,FINS,HOMA-IR and HOMA-βin the blood between these two groups were compared by determining Hcy,CysC,CRP,fasting blood glucose(FBG) and fasting insulin (FINS) in the blood.Then the correlation between Hcy,CysC,CRP and HOMA-IR,HOMA-βwere analyzed.Result:The levels of Hcy,CysC,CRP,FBG,FINS and HOMA-IR in the observation group were significantly higher than that in the control group(P<0.05).HOMA-β’s level between the two groups was compared,and the difference was not statistically significant(P>0.05).The levels of Hcy,CysC and CRP are positively correlated with HOMA-IR’s level(P<0.05),but there is no significant correlation between HOMA-β’s level and levels of Hcy,CysC and CRP (P>0.05).Conclusion:The levels of Hcy,CysC,CRP,FINS and HOMA-IR of GDM patients were significantly increased,and the levels of Hcy,CysC and CRP are positively correlated with HOMA-IR’s level.GDM patients have insulin resistance and low-grade inflammation.Inflammatory factors and insulin resistance are closely related.Inflammatory factors are involved in the occurrence and development of GDM.The determination of the levels of Hcy,CysC and CRP in the blood can be the monitoring indicators of patients with GDM.