The Preliminary Research on the Preparation Technology of Compound Pearl Buccal Tablet

LU Hong-zhi

Abstract：Objective:To explore the research on the basis of traditional pearl pill formula combined with modern technology to prepare the compound pearl buccal tablet.Method:Based on the traditional ancient prescription“pearl pill”,optimized the process conditions by the orthogonal design.The Extract rate and other kinds of main component content were observed,meanwhile analyzed the impact of components which were combined with added water and boiling time. So as to achieve the optimization of the original formula at the same time easy to suck it.Result:60%of the alcohol concentration was the best in the extraction of effective components.Glycyrrhizic acid content was increased,but Catalpa alcohol had no obvious change.60%of the alcohol concentration compared with other concentration of alcohol solution,differences were statistically significant(P<0.05).Alcohol precipitation had little effect on the content of oxalic acid,and catalpa alcohol content decreased obviously.Film forming good for adding lactose production.Conclusion:Summarized the research methods and results of this paper,the main steps of preparation of compound pearl buccal tablet and the method of maximum keep the effective components of dose can be clear.Not only it can retain the original main drug ingredients,but also it’s convenient for patients to take by made buccal tablet.