The Application of Lactoferrin in Oral Mucositis of Acute Lymphoblastic Leukemia Children with HD-MTX Chemotherapy

Abstract：Objective:To discuss and evaluate the effect of lactoferrin in the treatment of oral mucositis of leukemia children with chemotherapy and the safety.Method:350 cases of acute lymphocytic leukemia children with HD-MTX chemotherapy were accorded to the medical record number divided into control group and treatment group,175 cases in each group.Besides the leucovorin calcium rescue,clean Physiological saline gargle,and oral care by nystatin glycerol(after meals and before sleeping),the children in the treatment group were given lactoferrin 3 times/d and the control group in addition to giving a placebo were consistent with the treatment group.The incidence changes and healing time of oral mucositis children in various levels were recorded and compared,as well as the adverse reaction.Result:The incidence of oral mucositis in two groups had no obvious difference,but compared with the control group,the incidence ofⅢ,Ⅳlevels mucositis were significantly lower than that the treatment group.The cure rate of treatment group were higher and more efficient,the healing time of the treatment group in various levels were also significantly shorter than that the control group(P<0.05).Conclusion:Lactoferrin applied in oral mucositis of acute lymphoblastic leukemia children with HD-MTX chemotherapy is safe and effective.