Analysis of the Clinical Characteristics of Cytomegalovirus Pneumonia Accompanied with Multiple Organ Damage in Children

Abstract：Objective:To investigate clinical features of cytomegalovirus(CMV) pneumonia accompanied with multiple organ damage in children. Method:The clinical data of 120 cases with cytomegalovirus(CMV) pneumonia accompanied with multiple organ damage in children were retrospectively analyzed. Result:A total of 80 cases(66.7%) in 120 cases with CMV pneumonia were infants(0-1 years old).The major clinical manifestations were low heat,cough, wheezing,difficult breathing.Pulmonary symptoms were not obvious.There were 92 cases of extrapulmonary organ damage in all children,including 72 cases(78.3%) of 1-year-old,14 cases(15.2%) of 1-3 years old,6 cases(6.5%) of more than 3 years old.The major multiple damaged organs were the digestive system,blood, and the cardiovascular system.Its rates respectively were 87%,27.2%,26.1%.After treated with ganciclovir(GCV),102 cases(85.0%) were cured,18 cases(15.0%) improved.Auxiliary examination:120 cases of children were serum CMV-IgM positive and CMV-DNA positive in quantitative detection.There were 85 cases(70.8%) in lung interstitial changes in chest X-rays.Conclusion:Cytomegalovirus pneumonia in children mostly occurred within 1-year-old.The clinical symptoms,signs and chest X-rays lack specificity.This disease often accompanies with extrapulmonary organ damage,and is easily misdiagnosed.Ganciclovir in the treatment of this disease is safe and effective.