Study on the Clinical Effects of Two Doses of Mifepristone in Treating Uterine Leiomyoma

ZHAO Li

doi:10.3969/j.issn.1674-6805.2013.30.001

Abstract：Objective:To study the clinical effect of two doses of mifepristone in treatment of uterine intramural myoma patients,to explore the relationship between dose and effect.Method:89 cases of uterine intramural myoma were randomly selected in outpatient and inpatient department of our hospital,which were randomly divided into large dose group(44 cases) and small dose group(45 cases),the 25 mg/d dose treatment of large dose group;the 12.5 mg/d dose for the treatment of patients with small dose group.Two groups were compared before and after treatment of uterine size,size of tumor,serum FSH level,serum LH level, serum E2 level by statistical analysis,judging curative effect.Result:Low dose group and high dose group after treatment of uterus and uterine myoma volume was less than before treatment(P<0.05),but there were no statistically significant difference between the two groups before and after treatment(P>0.05);and before and after treatment LH,FSH,E2 level showed significant differences(P<0.05)in low dose group and high dose group;a statistical significance in comparison to the FSH level difference between the two groups after treatment(P<0.05).Conclusion:Application of low dose and high dose mifepristone had no significant difference with uterine intramural myoma patients in the clinical effect,but from the superior efficacy and safety concern we recommended use low does,long term effect need to more research.