The Effect and Mechanism of Ulinastatin on Myocardial Ischemia-reperfusion Injury
XIE Hao-kong
LI Jian-ping
XIE Jian-bo
Abstract：Objective:To investigate the effect and mechanism of Ulinastatin on myocardial ischemia-reperfusion injury in acute myocardial infarction and cardiopulmonary resuscitation (CPR).Method:A retrospective analysis of 63 cases of acute myocardial infarction in critically ill patients after CPR,according to whether using Ulinastatin,who were divided into conventional group (not used combination Ulinastatin group) and observed group (used Ulinastatin group).Heart rate (HR),mean arterial blood pressure (MBP),creatine kinase (CK-MB) and the rate of ventilator-associated pneumonia (VAP),were observed. Serum IL-6, TNF-α,MMP-9 levels were simultaneous detected of two groups and compared.Result:The mortality,VAP rates of observed group were 13.8%,6.9%,which were significantly lower than the conventional group 38.2%,32.4%,the difference was significant(P<0.05).The improvements of MBP,HR,CK-MB in observed group were significantly superior to the conventional group(P<0.05).The IL-6,TNF-α,MMP-9 of the two groups in the first day after CPR was no significantly different (P>0.05).After CPR five days,IL-6,TNF-α,MMP-9 increased compared with the first day,but the conventional group were significantly higher than the observed group(P<0.05).Conclusion:Ulinastatin can significantly reduce myocardial ischemia-reperfusion injury in AMI patients,reduce mortality and improve clinical outcomes,which may be related to inhibit inflammatory cytokine production and reduce inflammation injury.
Keywords：UlinastatinMyocardial ischemiaReperfusionInflammatory cytokines
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1-2,3 )