Relationship between Cystatin C and Acute Exacerbation of Chronic Obstructive Pulmonary Disease
SUN Zhen-gui
CHENG Yu-sheng
LU Zhi-wei
Abstract：Objective:To discover the relationship between Cys-c and AECOPD.Method:Retrospective analysis of all inpatients with AECOPD in department of respiratory,writer’s hospital during May 1 to November 30,2012.According to the inclusion criteria and exclusion criteria,54 patients with AECOPD confirmed by physical examination were randomly selected as AECOPD group,37 were male and 17 were female.Their average age was (66.98±8.07)years.Meanwhile,30 patients with stable COPD during the same period were selected as control group,21 were male and 9 were female.Their average age was (64.17±10.03)years.Serum creatinine, urea nitrogen,Cys-C,GFR and lengths of stay were recorded for above two groups.Result:Cys-C value of AECOPD group was significantly higher than control group, with (1.12±0.26)mg/L vs (0.95±0.23)mg/L respectively,there was significant difference(P=0.003).In AECOPD group,there were significant difference between Cys-C elevated subgroup and Cys-C normal subgroup for urea nitrogen level and length of stay,with (6.98±1.52)mmol/L vs (5.21±1.94)mmol/L(P=0.002) and (9.13±3.81) vs (7.23±2.41)days(P=0.033).Cys-C shared positive correlations with urea nitrogen and lengths of stay (P<0.05).Conclusion:Cys-C can reflect early renal impairment and is an important factor for affecting lengths of stay in patients with AECOPD.
Keywords：Cystatin CRenal functionAECOPD
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1-2,3 )