The Clinical Research on Leflunomide Jointed Sodium Ferulate in The treatment of Refractory Idiopathic Nephritic Syndrome
MIAO Xu
Abstract：Objective:To explore the curative effect that leflunomide jointed sodium ferulate in the treatment of refractory idiopathic nephritic syndrome. Method:80 patients were randomly divided into the treatment group and the control group,which have been diagnosed as refractory idiopathic nephritic syndrome in the Nephrology Department of our hospital from February 2012 to January 2013.Each group contained 40 patients.The methods of treatment in the control group consisted of cytotoxic drug (cyclophosphamide) and routine treatments,such as using glucocorticoid,diuresis,reducing urine protein,anti-hyperlipidemia and anticoagulation. Excepting the routine treatments,the treatment group also added that,oral leflunomide piece (25 mg bid,the first three days,then 25 mg qd),and sodium ferulate (0.3 g,iv drip qd). The treatment course was 1 month. One month later,we observed the changes of the clinical symptoms of nephrotic syndrome. In addition,we recorded the changes of 24 hours urinary protein,serum albumin,total cholesterol and quantitative serum creatinine,as well as the adverse drug reaction.Result:After 1 month of therapy,the complete response rates in the treatment group were significantly higher than the control group(P<0.001). In the meantime,24 hours urinary protein,total cholesterol and quantitative serum creatinine in the treatment group were significantly lower compared to the control group (P<0.05). On the contrary,the serum albumin was significantly higher in the treatment group(P<0.05).Conclusion:Leflunomide jointed sodium ferulate in the treatment of refractory idiopathic nephritic syndrome have an obvious positive effect.
Keywords：LeflunomideSodium ferulateRefractory idiopathic nephritic syndrome (RNS)
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 7-8 )