Lamivudine and Adefovir Combination Treatment for Compensatory Phase of the Study the Effect of Hepatitis B Cirrhosis of the Liver
GUO Jian-Bin
Abstract： Objective:To investigate the adefovir dipivoxil combined with lamivudine treatment for decompensated cirrhosis of hepatitis curative ef ect.Method:Choose compensatory period of 60 patients with hepatitis b cirrhosis serum HBV DNA positive,were randomly divided into observation group and control group,30 cases each. Observation group was given lamivudine and adefovir combination therapy,the control group given adefovir ester treatment,observe the two groups before treatment and 12, 24 and 48 weeks after treatment of liver function and HBV DNA ration.Result:At 8 weeks ALT recovery rate of observation group was obviously higher than that of control group,two groups compare difference was statistically significant (P<0.05);Serum HBV-DNA replication improvement group was significantly better than control group, two groups of comparisons difference was statistically significant (P<0.05).Conclusion:Lamivudine and adefovir combination therapy compensatory phase of hepatitis b cirrhosis of the liver can effectively inhibit HBV replication and obvious control disease progression and improve prognosis,is worthy of reference for clinical.
Keywords：Adefovir dipivoxilLamivudineDecompensated liver cirrhosis after hepatitis BCurative effect
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 37-37,38 )