Clinical Therapeutic Efficacy of Telmisartan Combined with Sodium Ferulate in Patients with Type 2 Diabetic Nephropathy Early
ZENG Guang-lan
Abstract： Objective:To investigate the clinical therapeutic efficacy of telmisartan combined with sodium ferulate in patients with type 2 diabetic nephropathy early(DN).Methods:120 DN patients were randomly divided into treatment group(n=60) and control group(n=60),and basal treatment was given to both groups.The treatment group was treated with telmisartan combined with sodium ferulate.Changes of blood lipid,plasma cystatin C(CysC) levels,endothelin-1(ET-1), nitric oxide(NO),and 24 h urinary albumin excretion rate(UAER),other metabolic parameters were observed,and the clinical effect of two groups were observed and compared after administration of the medicine for 4 weeks.Results:Compared with control group,TC,Cys C,LDL-C,ET-1 and UARE in treatment group were significantly decreased,but plasma NO,HDL-C,GFR levels were significantly increased (P<0.05 or P<0.01).The curative effects in the treatment group were significantly superior to those in control group(X2=10.909,P<0.01).Conclusion:Telmisartan combined with sodium ferulate has definite regulatory effect on the blood lipids in patients with DN,can improve endothelial function,decrease proteinuria,protect kindey,increase clinical therapeutic effect,is worth wide spread application.
Keywords：Diabetic nephropathyTelmisartanSodium ferulate
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 13-14,15 )